Oxaloacetate
General Information
Oxaloacetate (OAA) is a molecule in the energy creation cycle in the mitochondria (the powerhouse of the cell). OAA can increase muscle endurance and reduce fatigue in cells. In preliminary studies, OAA reduced physical and mental fatigue in ME/CFS and Long-COVID patients. It is also being studied for benefits in aging, inflammation, insulin regulation and neurodegenerative disorders.
Dosing Instructions
Please carefully follow your dosing instructions in your RTHM patient dashboard.
Please read this treatment guide in its entirety for additional important information.
Best Time to Take Oxaloacetate
Your last dose should be at least 5 hours before you plan on sleeping.
Take With or Without Food
Oxaloacetate should be taken with food.
What To Do If I Miss a Dose
If you miss a dose, take it as soon as possible. If you are close to the time of your next dose, wait to take the next dose and then resume your normal dosing schedule. Do not “double-up” the dose.
Precautions When Starting Oxaloacetate
- Read the medication guide and the dosing instructions in your RTHM patient portal before you start taking oxaloacetate. If you have any questions, message the RTHM Medical Team.
- Try to take your oxaloacetate at the same time each day.
- If you are on a stable dosage, do not increase or decrease the dose on your own without talking to your clinician first.
Potential Side Effects
Common side effects seen with oxaloacetate include:
- Difficulty sleeping
- Headache
- GI upset
- Constipation
- Feeling wired or anxious
When to Seek Medical Attention
Some side effects may require immediate medical attention. These can include:
- Kidney stones or pain
- Hives, rashes or anaphylaxis
Oxaloacetate can rarely cause serious allergic reactions in some individuals. If you experience rash, itching, trouble breathing, trouble swallowing, or swelling of the hands, face, or mouth, seek immediate medical attention.
Who Should Not Take Oxaloacetate
Oxaloacetate is not recommended for everyone. Do not take oxaloacetate if you have any of the following conditions
- Kidney disease or injury - Kidney injury can prevent the proper metabolism of oxaloacetate
- Kidney stones - Kidney injury can prevent the proper metabolism of oxaloacetate
- If you are allergic to oxaloacetate or Vitamin C
What If I Become Pregnant While Taking This Medication?
- Inform your doctor when you become pregnant. Because oxaloacetate is a medical food, there is very little information on pregnancy safety.
Medication Storage
- Keep this medication in the container provided by the supplier. Ensure it is properly closed and out of the reach of children. Store at room temperature and away from excess heat, direct light, and moisture (not in the bathroom).
- Do not share this medication with anyone else.
- Do not throw away unwanted or expired medications. Do not flush down the toilet or pour down the drain. Ask your local pharmacist about local drug take back programs to discard your medication.
In Case of Overdose
Take medication only as directed. In the event of an accidental overdose, contact emergency services immediately.
Questions?
If you have questions about this medication, please contact us by using our support form. We generally respond within 2 business days. If you have a more urgent issue, please seek care from your local primary care provider, urgent care or emergency services.
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